home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3279.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
35 lines
Document 3279
DOCN M94A3279
TI Darwinian evolution operates on the V3 region of HIV within a single
host.
DT 9412
AU Yamaguchi Y; Gojobori T; National Institute of Genetics, Shizuoka,
Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):112 (abstract no. PA0066). Unique
Identifier : AIDSLINE ICA10/94369296
AB OBJECTIVE: The purpose of this study is to elucidate the mechanisms of
molecular evolution of the third variable envelope (V3) region for HIV
within a single host. In particular, we intend to examine the patterns
of nucleotide substitutions in this region to see whether positive
selection is operating on the V3 region. METHODS: We constructed
phylogenetic trees by use of nucleotide sequences of HIV within a host.
We examined whether nonsynonymous (amino acid altering) substitutions
are occurring with a frequency higher than synonymous (silent)
substitutions. RESULTS: Our statistical test showed that for the V3
region, the average number of nonsynonymous substitutions was
significantly larger than that of synonymous substitutions. It suggests
that Darwinian evolution is operating on the V3 region. For the entire
env gene, however, the number of synonymous substitutions was larger
than that of nonsynonymous substitutions, implying that neutral
evolution is occurring in the entire env gene. DISCUSSION AND
CONCLUSIONS: Our observations indicate that Darwinian evolution may be
operating on the V3 region for HIV, although neutral evolution is
occuring in the entire env gene.
DE *Evolution *Genes, env Human HIV/*GENETICS/ISOLATION & PURIF HIV
Envelope Protein gp120/*GENETICS HIV Infections/MICROBIOLOGY Peptide
Fragments/*GENETICS Phylogeny Variation (Genetics) MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).